Large Hadron Collider
Initial capital letters. Always spell out first time (except in the CERN Courier), with abbreviation in brackets. Use the abbreviation thereafter.
Experiments at the Large Hadron Collider (LHC) suggest...
Beware of tautologies: Don't use "The LHC machine" or "The LHC accelerator", as this is equivalent to saying "The Large Hadron Collider accelerator...", which doesn't mean anything (the LHC doesn't accelerate accelerators).
Note: The Large Hadron Collider is a large machine that collides hadrons, not a machine that collides large hadrons (there is no such concept as a large hadron).